CONCERT –Silk-coated honeycomb nanocarriers for cancer therapy

Referência:

POCI-01-0145-FEDER-032651

PTDC/NAN-MAT/32651/2017

PI: Marlene Lúcio

CO-PI: M. Elisabete C.D. Real Oliveira

Resumo/Summary:

Nanoformulations for the administration of doxorubicin (DOX) in the treatment of cancer use “active loading” processes to reach higher doses with the disadvantage of having high toxicity and low therapeutic efficacy in DNA intercalation. CONCERT proposes the development of nanostructured lipid carriers (NLC) with an internal structure of honeycomb type for a greater encapsulation of DOX or graphene quantum dots conjugates (DOX@GQD) and cationic surface charge for conjugation with interfering ribonucleic acid (si-RNA), suppressor of multidrug resistance (MDR). The proposed NLC has a rigid coating that offers greater stability and active targeting to Her2 receptors overexpressed in cancer cells.  CONCERT strategies will bring several advantages: (i) improved therapeutic effect; (ii) increased selectivity for carcinogenic tissues; (iii) controlled release profile of the drug using GQD as pH switches sensitive to acidic tissues of the cancer. The nanoformulations developed will be compared with commercial therapies and tested in vitro on breast and ovarian cancer cells and in vivo on zebrafish embryos to assess their effectiveness as anticancer therapy.

Palavras chave:

 

Cancer nanotherapy

Graphene based nanomaterials

Lipid nanocarriers

pH-triggered drug delivery

Parceiros:

  • UNIVERSIDADE DO MINHO

Orçamento Global: 238 120,65 €

Orçamento UMinho: 238 120,65 €

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Apoio Financeiro UM

FEDER:  202 402.55€

OE: 35 718, 10€

Data início: 01/07/2018

Data Fim: 30/06/2021

Imagem ilustrativa

CONCERT Silk coated honeycomb nanocarriers for cancer therapy

Financiamento:

FEDER, OE

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