Referência:

POCI-01-0145-FEDER-028020

PTDC/QUI-QFI/28020/2017

PI: Paulo Coutinho

CO-PI: Elisabete M. S. Castanheira Coutinho

Objetivo:

Reforçar a investigação, o desenvolvimento tecnológico e a inovação.

 

Resumo/Summary:

In this project, drug nanocarriers based in magnetoliposomes will be developed for application in dual cancer therapy, combining the potential of chemotherapy and magnetic hyperthermia in a single nanosystem. Biocompatible magnetic nanoparticles will be prepared and incorporated into liposomes. Both solid and aqueous magnetoliposomes will be obtained.
New drug candidates with promising antitumor activity will be incorporated in magnetoliposomes. The antitumor potential of drug loaded magnetoliposomes will be evaluated in human tumor cell lines, as well as the toxicity for non-tumor cells.
The ultimate goal is to obtain multifunctional nanosystems with optimized drug delivery and local heating capabilities, for dual cancer therapy.

Palavras chave:

Magnetic nanoparticles

Magnetoliposomes

Hyperthermia

Controlled drug delivery

Parceiros:

  • UNIVERSIDADE DO MINHO (UMINHO)
  • FACULDADE DE ENGENHARIA DA UNIVERSIDADE DO PORTO (FEUP)
  • INSTITUTO POLITÉCNICO DE BRAGANÇA

Orçamento Global: 237 458,17€

Orçamento UMinho: 158 483, 17€

 

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Apoio Financeiro UM 

FEDER: 134 710, 69€

OE: 23 772, 48€

Data início: 01/07/2018

Data Fim: 30/06/2021

Imagem alusiva ao projeto (opcional)

magliduo

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Financiamento:

FEDER, OE

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